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Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. Glucose control was three times more pronounced when rimonabant was added than with insulin treatment and lifestyle advice alone. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Food and Drug Administration finding of increased risk of suicide during treatment with rimonabant, we recommend increased alertness by physicians to these potentially severe psychiatric adverse reactions. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of Zimulti (rimonabant) to the US FDA for use in obese and overweight patients with associated risks factors because of continuing concerns about increased risks for suicidal thoughts among some users. 15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. Rimonabant is not yet accustomed for use in the United States, area it is accepted as Zimulti. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. Food and Drug Administration panel recommended that rimonabant should not be given the FDA's blessing because of continuing concerns about increased risks for suicidal thoughts among some users.

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